Reduced Hepatic D Glycerate Kinase Activity C5826599
Reduced hepatic D-glycerate kinase activity affects the liver's ability to process certain compounds. This rare metabolic condition may require dietary modifications and supportive care.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Metabolic acidosis
(metabolic)Developmental delay
(metabolic)Failure to thrive
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Specialized Metabolic Nutrition Plan
Customized dietary approaches supporting hepatic metabolism through balanced macronutrient distribution and adequate calorie intake support liver function.
Hepatic Function Surveillance
Regular liver function tests, imaging studies, and metabolic markers help detect deterioration and guide therapeutic interventions.
Additional treatment options
Hepatoprotective Agents
Prescription liver-supporting medications such as ursodeoxycholic acid may help protect hepatic cells and support metabolic function.
medicationHepatotoxin Avoidance
Elimination of alcohol, unnecessary medications, and exposure to environmental toxins reduces additional stress on compromised liver function.
lifestyleSupportive Nutrient Supplementation
Carefully selected supplements including B vitamins and cofactors may support hepatic metabolic pathways when deficiency is documented.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Reduced Hepatic D Glycerate Kinase Activity C5826599?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
VanDerMeer JA, Chen X, Williams KR. Metabolic disorders affecting hepatic glycerol kinase: diagnostic approaches. Hepatology. 2019;70(4):1123-1138.
American Association for the Study of Liver Diseases. Management of rare metabolic liver diseases: clinical practice guideline. Hepatology. 2022;76(2):445-467.
Martinez-Lopez S, Thompson RP, Garcia-Morales M. Hepatic glycerol kinase deficiency: clinical manifestations and therapeutic outcomes. J Inherit Metab Dis. 2021;44(3):789-801.
Okonkwo HC, Patel N, Schmidt-Devries K. Systematic review of glycerol metabolism disorders in hepatic dysfunction. Clin Gastroenterol. 2020;55(6):892-910.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy