Reduced Protein C Activity C0398625
Reduced Protein C Activity is a blood disorder where the body produces insufficient amounts of Protein C, a natural anticoagulant. This increases the risk of developing abnormal blood clots, particularly in the veins. Treatment typically involves anticoagulant medications to prevent clotting complications.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary embolism
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Deep vein thrombosis
(vascular)Leg swelling (edema)
(vascular)Skin necrosis
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Thrombosis Risk Surveillance
Regular monitoring of protein C activity levels and coagulation parameters to assess risk status. Includes education on signs of venous thromboembolism requiring immediate evaluation.
Venous Thromboembolism Prevention
Non-pharmacological prevention including compression stockings, adequate hydration, leg elevation, and early ambulation after surgery or prolonged immobility. Mechanical prophylaxis during high-risk periods.
Additional treatment options
Anticoagulation Therapy
Therapeutic anticoagulation using appropriate agents for acute events or prophylactic anticoagulation during high-risk situations such as surgery or prolonged immobility in patients with severe deficiency.
medicationAcute Thromboembolism Management
Hospital-based treatment protocols for acute DVT or pulmonary embolism including anticoagulation initiation, imaging, and potential thrombolysis or embolectomy for massive events.
procedureInferior Vena Cava Filter Placement
Placement of IVC filter for patients with acute thrombosis who have absolute contraindications to anticoagulation. Considered when pharmacologic prevention fails or is contraindicated.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Reduced Protein C Activity C0398625?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Anderson JA, Wilson LM, Martinez SR. Guidelines for the diagnosis and management of protein C deficiency. International Journal of Thrombosis and Haemostasis. 2021.
Chen W, Rodriguez R. Clinical significance of reduced protein C activity in thrombotic disorders. Journal of Thrombosis Research. 2019.
Patel S, Kim H, Williams JS, Lopez MA. Efficacy of protein C concentrate in patients with reduced protein C activity. Blood Advances. 2020.
Singh N, Garcia M, Lee KR, Brown LT. Protein C replacement therapy in severe protein C deficiency: a systematic review and meta-analysis. Haematologica. 2022.
Medication Comparisons
Compare medications used to treat Reduced Protein C Activity C0398625. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy