Retinopathy Of Prematurity Zone Ii C4703699
An eye disease affecting premature infants where abnormal blood vessels grow in the retina. Early detection and treatment with laser or injections can help prevent permanent vision loss.
Key facts at a glance
- ICD-10
- H53.9
- ICD-11
- 9A00.0
- Body system
- ophthalmologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Retinal detachment
Leukocoria
Reduced visual acuity
Generalized symptoms
(ophthalmologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Abnormal retinal vascularization
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Laser photocoagulation
Laser therapy is applied to the peripheral retina to reduce abnormal blood vessel growth and prevent progression of retinopathy. This outpatient procedure is performed under anesthesia in premature infants.
Anti-VEGF intravitreal injections
Vascular endothelial growth factor inhibitors are injected into the eye to block abnormal blood vessel formation. This treatment may be used alone or in combination with laser therapy for advanced cases.
Additional treatment options
Cryotherapy
Cryotherapy involves freezing abnormal retinal tissue to destroy it and reduce vascular proliferation. This treatment is typically reserved for cases where laser therapy is not feasible.
procedureRegular ophthalmologic screening
Serial eye examinations by a pediatric ophthalmologist are essential for detecting progression and determining optimal treatment timing. Imaging technologies help track disease evolution.
monitoringVitrectomy
Surgical removal of the vitreous and scar tissue may be necessary for advanced cases with retinal detachment. This complex procedure is reserved for severe ROP that does not respond to other treatments.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Retinopathy Of Prematurity Zone Ii C4703699?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fierson WM, American Academy of Pediatrics Section on Ophthalmology. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2018.
Chen ML, Stahl A, Hellstrom A. Current update on retinopathy of prematurity: screening and treatment. Eye. 2021.
Mintz-Hittner HA, Kennedy KA, Chuang AZ. Efficacy of intravitreal bevacizumab for stage 3+ retinopathy of prematurity. N Engl J Med. 2011.
Sankar MJ, Sankar J, Mehta M. Anti-vascular endothelial growth factor for type 1 retinopathy of prematurity: a systematic review and meta-analysis. JAMA Ophthalmol. 2022.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy