Rhabdomyolysis Susceptibility To 1 C5774307
A genetic condition where muscles break down easily, releasing harmful substances into the blood. It can be triggered by exertion or illness. Treatment focuses on preventing episodes and protecting the kidneys.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Myoglobinuria
Acute kidney injury
Exercise intolerance
(musculoskeletal)Joint pain or stiffness
(musculoskeletal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Muscle pain with exertion
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Exercise Modification Program
Structured activity program avoiding high-intensity anaerobic exercises and extreme temperature exposure that trigger rhabdomyolysis episodes. Graduated conditioning under supervision.
Creatine Kinase Monitoring and Management
Baseline and triggered CK level monitoring with prophylactic or acute treatment protocols. May include dantrolene sodium for malignant hyperthermia-like presentations or general supportive care.
Additional treatment options
Hydration Optimization Protocol
Maintaining optimal hydration status especially during illness, exercise, or heat exposure to prevent muscle breakdown and protect renal function.
lifestyleMetabolic Supportive Nutrition
Dietary optimization with adequate carbohydrates for energy, appropriate protein intake, and avoidance of fasting states that may precipitate episodes. Individualized based on underlying metabolic defect.
dietaryGenetic Testing and Counseling
Confirmatory genetic diagnosis identifying specific mutation affecting ryanodine receptor or other muscle calcium channels. Enables family counseling and carrier testing.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Rhabdomyolysis Susceptibility To 1 C5774307?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bosquet J, Garnier C. European Guidelines for the Management of Rhabdomyolysis and Related Syndromes. Eur J Neurol. 2022.
Torres PA, Helmstetter JA, Kaye AM. Metabolic Myopathies and Rhabdomyolysis Susceptibility: A Clinical Review. Muscle Nerve. 2021.
Nance JR, Mammen AL. Evaluation and Diagnosis of Rhabdomyolysis in Practice Settings. JAMA Neurol. 2020.
Wagner KR, DeChene ET. Rhabdomyolysis and Myoglobinuria. In: Swaiman's Pediatric Neurology, 7th ed. Philadelphia: Elsevier; 2023.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy