Rhabdomyolysis Susceptibility To 2 C6012738
A genetic susceptibility to muscle breakdown that can cause severe complications. It may be triggered by various factors. Careful management and avoiding triggers are important.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Dark urine following exercise
Severe generalized muscle pain
Chronic kidney disease
Joint pain or stiffness
(musculoskeletal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent muscle breakdown episodes
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Acute Rhabdomyolysis Emergency Protocol
Immediate hospitalization protocol including aggressive IV hydration, electrolyte management, and renal function monitoring when CK levels exceed critical thresholds or myoglobinuria present.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Trigger Avoidance and Activity Counseling
Comprehensive education identifying and avoiding personal triggers including certain medications, infections, temperature extremes, and exercise intensity that precipitate rhabdomyolysis episodes.
Additional treatment options
Chronic CK Level Surveillance
Periodic serum creatine kinase monitoring to establish baseline and detect subclinical elevation indicating ongoing muscle membrane instability or nascent episodes.
monitoringMuscle Health Nutritional Support
Optimized nutrition supporting muscle integrity including adequate vitamin D, electrolytes (potassium, magnesium), and avoidance of carnitine deficiency if metabolic etiology.
dietaryChronic Condition Coping Support
Psychological support addressing anxiety about activity participation, fear of episodes, and quality of life impacts of living with susceptibility to recurrent rhabdomyolysis.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Rhabdomyolysis Susceptibility To 2 C6012738?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stanislaus J, Kley RA, Tarnopolsky MA. Clinical practice guideline for the management of rhabdomyolysis. Muscle Nerve. 2022.
Scalco RS, Gardiner AR, Pitceathly RD. Metabolic myopathies and rhabdomyolysis susceptibility: a comprehensive review. J Neurol. 2020.
Nationen J, Uusimaa J, Herva R. Genetic predisposition to exercise-induced rhabdomyolysis: a prospective cohort study. Neurology. 2018.
Vasquez LO, Martinez PY, Chen JJ. Diagnostic biomarkers in rhabdomyolysis susceptibility: systematic review and meta-analysis. Ann Neurol. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy