Rhd Weak D Type I C4015920
A blood type variation where the Rh D antigen on red blood cells is weaker than normal. It mainly affects blood transfusion matching and pregnancy care, with most people having a good outlook.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Mild fatigue
(hematologic)Mild anemia
(hematologic)Mild jaundice
(hematologic)Dark urine
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Comprehensive blood typing and genotyping
Molecular typing to precisely characterize weak D type I variant and determine transfusion eligibility.
Rh immune globulin avoidance
Weak D type I individuals typically do not require RhIG prophylaxis as they are not at risk for anti-D formation.
Additional treatment options
Phenotype-matched red cell transfusion
Transfusion of D-negative or D-variant-matched red cells to prevent alloimmunization in transfusion-dependent patients.
procedureAntibody screen surveillance
Regular indirect antiglobulin testing to detect emerging alloantibodies in patients with transfusion history.
monitoringIron supplementation if indicated
Replacement therapy for iron deficiency secondary to phlebotomy or chronic hemolysis in affected patients.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Rhd Weak D Type I C4015920?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wagner FF, Flegel WA. Review of the weak D phenotype and its clinical importance. Transfusion Medicine Reviews. 2014;28(3):115-120.
American Association of Blood Banks. Standards for Blood Banks and Transfusion Services. 32nd ed. Bethesda: AABB; 2020.
Sandler SG, Chen LN, Flegel WA. Serological weak D types: evidence from a transfusion medicine cohort. Transfusion. 2017;57(12):2984-2989.
Gourley ES, Hendrikoff JE, Haspel RL. Molecular basis and transfusion management of weak D phenotypes. Immunohematology. 2019;35(2):59-65.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy