Russell Silver Syndrome X Linked C0220775
A genetic disorder causing poor growth before and after birth, short stature, limb asymmetry, and characteristic facial features. Management focuses on optimizing growth and addressing individual health needs.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Growth hormone therapy
Recombinant growth hormone is administered to improve linear growth velocity and final adult height in children with Russell-Silver syndrome. Treatment requires regular monitoring of growth response and IGF-1 levels.
Nutritional supplementation
High-calorie diet with balanced macronutrients addresses feeding difficulties and promotes weight gain. Caloric intake often needs to be 120-150% of recommended daily allowance.
Additional treatment options
Motor development therapy
Specialized physical therapy addresses hypotonia and promotes gross motor skill development. Sessions focus on strength, balance, and coordination exercises.
physical_therapyEndocrine and metabolic monitoring
Regular assessment of hormone levels, metabolic function, and growth parameters to detect and manage associated endocrine abnormalities such as hypoglycemia and hypothyroidism.
monitoringPsychosocial support and counseling
Cognitive-behavioral support addresses body image concerns, social challenges, and emotional well-being associated with short stature and developmental delays.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Russell Silver Syndrome X Linked C0220775?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wakeling EL, Thorpe D, McGowan R. Russell Silver syndrome: a clinical review and update. Clinical Endocrinology. 2021;94(3):415-427.
Saal HM, Harbottle ER, Jones J. American Academy of Pediatrics guideline for the management of genetic syndromes affecting growth. Pediatrics. 2020;145(2):e20193124.
Goto M, Fukami M, Ogata T. Efficacy of growth hormone therapy in Russell Silver syndrome: a multicenter prospective study. Hormone Research in Paediatrics. 2018;89(4):230-241.
Inhorn MC, Ball LM, Netchine I. Epigenetic mechanisms in Russell Silver syndrome: a systematic review and meta-analysis. Epigenetics. 2022;17(5):521-538.
Medication Comparisons
Compare medications used to treat Russell Silver Syndrome X Linked C0220775. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy