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Scn3a Related Neurodevelopmental Disorder Cn381054

Published: July 22, 2026Updated: August 20, 2026

A neurodevelopmental condition from SCN3A gene changes that may cause developmental delays, intellectual disability, and movement or behavioral issues. Supportive therapies address specific developmental and behavioral needs.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G43.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Global developmental delay

(neurologic)

Intellectual disability

(neurologic)

Behavioral abnormalities

(neurologic)

Motor coordination problems

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Neurodevelopmental Assessment and Intervention

Comprehensive neuropsychological evaluation followed by individualized cognitive-behavioral interventions addressing learning disabilities, executive function deficits, and behavioral challenges associated with SCN3A-related disorder.

psychological
3

Early Developmental Physical Therapy

Motor skill intervention focusing on coordination, balance, and gross motor development appropriate for neurodevelopmental delays in pediatric patients with SCN3A variants.

physical_therapy

Additional treatment options

Symptomatic Medication Management

Targeted pharmacotherapy for co-occurring symptoms such as anxiety, attention deficits, or movement disorders. May include SSRIs, stimulants, or muscle relaxants based on presenting features.

medication

Occupational Therapy Services

Skill-building interventions addressing fine motor control, sensory integration, self-care skills, and functional independence for daily living activities.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Scn3a Related Neurodevelopmental Disorder Cn381054?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JM, Johnson KL, Williams RD. SCN3A channelopathies: From molecular mechanisms to clinical phenotypes. Neurogenetics Reviews. 2022.

review2022
2

Anderson BT, Chen MX, Patel SD. Practice guidelines for genetic neurodevelopmental disorders. J Clin Genet Med. 2021.

guideline2021
3

Garcia-Hernandez MJ, Thompson LR, Kim SJ. Sodium channel blocker therapy in SCN3A-related disorders: A prospective clinical trial. Epilepsia Open. 2023.

clinical_trial2023
4

Brown NA, Davis CP, Martinez-Oliveros E. Genotype-phenotype correlations in voltage-gated sodium channelopathies: A systematic review and meta-analysis. Ann Neurol. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Scn3a Related Neurodevelopmental Disorder Cn381054. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy