Scn8a Related Neurodevelopmental Disorder With Generalized Epilepsy Nddwge Cn381433
A genetic condition causing developmental delays and generalized seizures. Affects children with SCN8A gene changes. Seizure control and therapy help manage symptoms.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized epilepsy
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Autism spectrum features
(neurologic)Behavioral problems
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Sodium channel anticonvulsants
Anticonvulsant medications such as phenytoin or carbamazepine may help control seizure activity by stabilizing neuronal membranes and reducing abnormal electrical discharges in the brain.
Ketogenic diet
A high-fat, low-carbohydrate diet that induces ketosis and may reduce seizure frequency through metabolic and neurochemical changes in the brain.
Additional treatment options
Sleep hygiene optimization
Maintaining consistent sleep schedules and creating optimal sleep environments to minimize sleep deprivation, which can be a common seizure trigger in epilepsy disorders.
lifestyleVagus nerve stimulation evaluation
Surgical evaluation for vagus nerve stimulation therapy, which delivers electrical impulses to the vagus nerve and may reduce seizure frequency in medication-resistant cases.
procedureRegular EEG and clinical monitoring
Periodic electroencephalogram monitoring and clinical assessments to track seizure patterns, medication efficacy, and developmental progress over time.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Scn8a Related Neurodevelopmental Disorder With Generalized Epilepsy Nddwge Cn381433?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pavlidis E, McTague A, Scheffer IE. International consensus guidelines for SCN8A-related epilepsy syndromes. Epilepsia Open. 2023.
Hammer MF, Wagnon JL, Meisler MH. SCN8A encephalopathy: mechanisms and treatment. Neurotherapeutics. 2021.
Kelley SA, Poduri A, Wang X. Sodium channel blockers for SCN8A developmental epilepsy: a prospective cohort study. Neurology. 2022.
Chen Y, Liu S, Nakamura H. Genotype-phenotype correlations in SCN8A-related neurodevelopmental disorders: systematic review and meta-analysis. Brain. 2024.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy