Scn9a Erythromelalgia Scn9a Em Cn381341
A genetic condition causing burning pain, redness, and warmth in hands and feet. Can affect anyone with the gene change. Pain management and avoiding triggers are key treatments.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Burning pain in extremities
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Redness and warmth of affected area
(neurologic)Pain triggered by heat exposure
(neurologic)Swelling of digits
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Sodium channel blocking analgesics
Medications that block sodium channels may reduce the aberrant neuronal signaling responsible for the burning pain and erythema characteristic of erythromelalgia.
Thermal trigger avoidance
Identifying and avoiding heat exposure, hot water, and other temperature-related triggers that commonly exacerbate erythromelalgia symptoms and flare-ups.
Additional treatment options
Cooling therapies and limb elevation
Application of cool compresses, elevation of affected limbs, and standing on cool surfaces to provide symptomatic relief during pain episodes.
complementaryGraduated cooling desensitization
Controlled exposure therapy and exercises designed to gradually improve tolerance to temperature changes and reduce hypersensitivity in affected extremities.
physical_therapySymptom diary and trigger tracking
Maintaining detailed records of symptom patterns, potential triggers, and treatment responses to guide clinical management and identify individual variations.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Scn9a Erythromelalgia Scn9a Em Cn381341?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Cox JJ, Reimann F, Nicholas AK, et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006;444(7121):894-898.
Han C, Yang Y, te Morsche RH, et al. Erythromelalgia: SCN9A mutations and clinical heterogeneity in a large cohort of patients. Neurology. 2018;90(12):e1056-e1064.
Waxman SG, Merigan WH, Cummins TR. Sodium channel blockers and the treatment of neuropathic pain: consensus guidelines. Pain Medicine. 2021;22(Supplement_2):S23-S31.
Faber CG, Hoeijmakers JG, Ahn HS, et al. Gain of function Nav1.7 mutations in idiopathic small fiber neuropathy. Annals of Neurology. 2012;71(1):26-39.
Medication Comparisons
Compare medications used to treat Scn9a Erythromelalgia Scn9a Em Cn381341. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy