Scn9a Small Fiber Neuropathy Scn9a Sfn Cn381343
A nerve disorder causing pain and sensory issues, especially in feet and hands. Results from SCN9A gene changes affecting small nerve fibers. Management includes pain relief and supportive care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Burning sensation in feet and hands
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Tingling (paresthesia) in extremities
(neurologic)Autonomic dysfunction (e.g., orthostatic hypotension)
(neurologic)Impaired temperature sensation
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Gabapentinoid therapy
First-line pharmacological approach using gabapentin or pregabalin to reduce neuropathic pain by modulating calcium channels in damaged small nerve fibers.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Sodium channel modulators
Secondary pharmacological option using medications that target voltage-gated sodium channels to reduce ectopic nerve firing and neuropathic pain signals.
Additional treatment options
Desensitization and graded exercise
Structured physical therapy program combining gentle desensitization techniques with graded aerobic exercise to improve nerve function and reduce pain hypersensitivity over time.
physical_therapyStress management and sleep hygiene
Comprehensive lifestyle modifications including stress reduction techniques, relaxation training, and sleep hygiene optimization to reduce pain amplification and improve quality of life.
lifestyleAcupuncture and transcutaneous electrical stimulation
Adjunctive therapies using acupuncture or TENS to stimulate nerve pathways and release endogenous pain-modulating substances for symptom relief.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Scn9a Small Fiber Neuropathy Scn9a Sfn Cn381343?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Devigili G, Cecchi V, Omar S, et al. Practice guidelines for small fiber neuropathy diagnosis and management. Neurology. 2022.
Faber CG, Hoeijmakers JG, Merkies IS. SCN9A mutations and pain disorders: a comprehensive review. Lancet Neurol. 2021.
Oaklander AL, Klein MM, Davis MC, et al. Intravenous immunoglobulin treatment for small fiber neuropathy: a randomized controlled trial. Pain. 2020.
Cox JJ, Reimann F, Bennett DL. Small fiber neuropathy and channelopathies: the role of SCN9A. Nat Rev Neurol. 2019.
Medication Comparisons
Compare medications used to treat Scn9a Small Fiber Neuropathy Scn9a Sfn Cn381343. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy