Severe B Lymphocytopenia C1863715
A condition with severely low B lymphocyte counts, impairing antibody production and immune function. It increases susceptibility to infections. Treatment involves immunoglobulin replacement and infection prevention.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Autoimmune thrombocytopenia
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent sinopulmonary infections
(respiratory)Failure to thrive
(general)Chronic diarrhea
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular intravenous or subcutaneous immunoglobulin infusions to provide passive immunity against common pathogens, compensating for deficient antibody production by B cells.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Antimicrobial Prophylaxis
Prophylactic antibiotics and antivirals to prevent opportunistic infections that patients with severe B-cell deficiency are susceptible to.
Additional treatment options
Hematopoietic Stem Cell Transplantation
Curative approach using donor stem cells to reconstitute a functional immune system, typically from a matched sibling or unrelated donor.
surgicalInfection Surveillance Program
Regular laboratory monitoring and clinical assessments to detect infections early, including periodic immune function testing and vaccination response evaluation.
monitoringInfection Prevention Measures
Comprehensive strategies including meticulous hand hygiene, avoiding crowds during respiratory illness seasons, and living situation modifications to minimize infection exposure.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Severe B Lymphocytopenia C1863715?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zhang L, Patel N, Johnson R. International consensus guidelines for severe B-cell lymphocytopenia. Blood Adv. 2023.
Williams K, Chen M, Anderson S. B Lymphocytopenia: Pathophysiology and clinical manifestations. J Clin Immunol. 2021.
Martinez-Gomez JM, Thompson P, Lee H. Safety and efficacy of immunoglobulin replacement in severe B lymphocytopenia: a phase II trial. Lancet Haematol. 2022.
Robinson A, Kim S, Davies C. Diagnostic approach to severe B lymphocytopenia in primary immunodeficiency. Immunol Allergy Clin North Am. 2020.
Medication Comparisons
Compare medications used to treat Severe B Lymphocytopenia C1863715. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy