Severe Hemophilia A C0272322
Hemophilia A is an X-linked bleeding disorder caused by deficiency of clotting factor VIII. Affected males experience spontaneous bleeding into joints and muscles. Treatment involves regular replacement of the missing clotting factor to prevent and control bleeding.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spontaneous joint bleeding (hemarthrosis)
(hematologic)Deep muscle bleeding (hematoma)
(hematologic)Prolonged bleeding after injury or surgery
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Factor VIII Replacement Therapy
Intravenous infusion of recombinant or plasma-derived factor VIII to replace the missing clotting factor. This is the cornerstone of hemophilia A treatment, allowing for control of bleeding episodes and prevention of joint damage.
Prophylactic Factor VIII Regimen
Regular scheduled infusions of factor VIII to maintain minimum factor levels and prevent spontaneous bleeding. This approach is particularly important in severe hemophilia to protect joints and enable normal physical activity.
Additional treatment options
Bleeding Precautions and Activity Modification
Education on avoiding trauma-prone activities, proper wound care techniques, and use of protective equipment. Patients learn to recognize early signs of bleeding and when to seek medical attention.
lifestyleJoint Protection and Rehabilitation
Specialized physical therapy focusing on muscle strengthening around joints, particularly knees, ankles, and elbows, to provide better structural support and reduce bleeding risk. Includes techniques for managing hemarthrosis.
physical_therapyRegular Coagulation and Inhibitor Monitoring
Periodic laboratory testing to assess factor VIII levels, inhibitor screening, and joint health through imaging. Enables treatment plan optimization and early detection of complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Severe Hemophilia A C0272322?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Srivastava A, Brewer AK, Mauser-Bunschoten EP, et al. WFH Guidelines for the Management of Hemophilia, 3rd Edition. Haemophilia. 2020;26(Suppl 6):1-158.
Mannucci PM, Tuddenham EGD. The Hemophilias: From Royal Genes to Gene Therapy. N Engl J Med. 2021;384(22):2023-2034.
Mahlangu J, Oldenburg J, Paz-Priel I, et al. Emicizumab Prophylaxis in Patients with Hemophilia A without Inhibitors. N Engl J Med. 2018;379(9):811-822.
Coppola A, Di Capua M, Di Minno MN, et al. Treatment of Hemophilia: A Review of Current Achievements and Challenges. Blood Rev. 2022;41:100709.
Medication Comparisons
Compare medications used to treat Severe Hemophilia A C0272322. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy