Severe T Cell Immunodeficiency C4025208
A severe weakness in infection-fighting immune cells, leaving patients highly vulnerable to serious infections. Treatment includes infection prevention and possible bone marrow transplant.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent sinopulmonary infections
Autoimmune cytopenias
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Persistent oral candidiasis
(integumentary)Severe warts
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
When to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Severe T Cell Immunodeficiency C4025208?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Cunningham-Rundles C, Sathya B. Severe Combined Immunodeficiency: Pathogenesis and Management. Immunol Allergy Clin North Am. 2020.
Notarangelo LD, Fischer A, Geha RS, et al. International Consensus Document on Primary Immunodeficiency Disorders: Guidelines for Management of Severe T Cell Deficiencies. J Clin Immunol. 2022.
Haddad E, Hoenig M, Albert MH, et al. Hematopoietic Stem Cell Transplantation for Severe T Cell Immunodeficiency: Long-Term Outcomes from Fourteen International Centers. Blood. 2021.
Dvorak CC, Cowan MJ, Logan BR, et al. A Systematic Review and Meta-Analysis of Gene Therapy for Primary Immune Deficiencies: Outcomes and Complications. Biol Blood Marrow Transplant. 2023.
Medication Comparisons
Compare medications used to treat Severe T Cell Immunodeficiency C4025208. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy