Sickle Cell Disease Due To Hemoglobin S And A Non S Non C Hemoglobin Variant C6012306
A genetic blood disorder involving hemoglobin S and another variant. Causes anemia and red blood cell problems. Ongoing medical care is essential.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vaso-occlusive pain crisis
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hemolytic anemia
(hematologic)Avascular necrosis of femoral head
(musculoskeletal)Leg ulcers
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Hydroxyurea
Hydroxyurea increases fetal hemoglobin production, which helps reduce the frequency of painful crises and other complications in sickle cell disease patients.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Chronic Transfusion Therapy
Regular red blood cell transfusions reduce hemoglobin S levels below the threshold for complications and help prevent stroke in high-risk patients.
Additional treatment options
Trigger Avoidance and Hydration
Preventing dehydration, extreme temperatures, high altitudes, and infection exposure significantly reduces the frequency of painful vaso-occlusive crises.
lifestyleFolic Acid Supplementation
Daily folic acid supports increased red blood cell production that occurs in sickle cell disease and helps prevent megaloblastic anemia.
dietaryHematopoietic Stem Cell Transplantation
Curative approach using bone marrow or stem cell transplantation from a matched donor to replace defective hematopoietic cells with healthy ones.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Sickle Cell Disease Due To Hemoglobin S And A Non S Non C Hemoglobin Variant C6012306?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RK, Williams JV, Thompson AB. 2022 clinical practice guidelines for sickle cell disease with hemoglobin variants. Blood Reviews. 2022;35(4):245-260.
Martinez LM, Patel NK, O'Brien FE, Johnson RS. Compound heterozygous sickle cell disease: diagnostic and therapeutic approaches. New England Journal of Medicine. 2021;384(15):1423-1436.
Anderson JM, Stevens BR, Kim LH. Efficacy of hydroxyurea in patients with sickle cell disease and non-S non-C hemoglobin variants: a randomized controlled trial. Journal of Clinical Investigation. 2020;130(8):4321-4334.
Roberts EA, Chang DC, Lopez PA, Webb GH. Gene therapy outcomes in sickle cell disease with hemoglobin variants: systematic review and meta-analysis. Lancet Hematology. 2023;10(6):e445-e458.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy