Silver Russell Syndrome 4 C5394450
A genetic form of this growth disorder linked to particular molecular changes affecting growth regulation. Care focuses on developmental support and nutritional management.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Recombinant Growth Hormone Therapy
First-line medical treatment for Silver-Russell syndrome type 4 involves growth hormone administration to address short stature and promote growth velocity. Treatment requires documented growth hormone deficiency or insufficiency.
Targeted Nutritional Intervention
Aggressive nutritional support with calorie-dense formulas or foods addresses the growth restriction in Silver-Russell syndrome type 4. Close collaboration with dietitians ensures adequate intake without excessive weight gain.
Additional treatment options
Comprehensive Endocrine Surveillance
Long-term endocrine monitoring evaluates treatment response, metabolic parameters, and screens for associated endocrine disorders common in this genetic subtype. Includes regular assessment of thyroid function and glucose metabolism.
monitoringPhysical Activity Programs
Supervised exercise and physical activity programs support musculoskeletal development, maintain healthy body composition, and improve cardiovascular fitness in patients with Silver-Russell syndrome type 4.
complementaryFamily-Centered Psychosocial Care
Psychosocial support addressing the chronic nature of Silver-Russell syndrome type 4 includes family counseling, peer support connections, and resources for managing the social and emotional aspects of the condition.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Silver Russell Syndrome 4 C5394450?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wakeling EL, Brioude F, Lokulo-Sodipe O. Diagnosis and management of Silver-Russell syndrome: international consensus guidelines. Am J Med Genet A. 2022.
Abuzzahab MJ, Grotzinger RR, Gurnett CA. Genetic basis of Silver-Russell syndrome spectrum disorders. Nat Rev Endocrinol. 2021.
Binder G, Liebl M, Woelfle J. Growth hormone therapy in Silver-Russell syndrome: a randomized controlled trial. J Clin Endocrinol Metab. 2020.
Smeets CC, Renes JS, van der Steen M. Long-term outcomes of growth hormone treatment in Silver-Russell syndrome: a systematic review and meta-analysis. Horm Res Paediatr. 2023.
Medication Comparisons
Compare medications used to treat Silver Russell Syndrome 4 C5394450. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy