Silver Russell Syndrome 5 C5394456
A variant of this growth restriction syndrome caused by specific genetic changes, resulting in prenatal and postnatal growth failure. Treatment involves multidisciplinary care and growth monitoring.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Growth Hormone Therapy
Recombinant growth hormone treatment is the primary therapeutic approach for Silver Russell Syndrome to improve linear growth velocity and final adult height. Treatment is typically initiated in early childhood after comprehensive endocrine evaluation and is continued until growth velocity declines.
Nutritional Support and Caloric Optimization
Comprehensive nutritional assessment and intervention to address feeding difficulties and optimize caloric intake for catch-up growth. May include high-calorie formulas, fortified foods, and feeding therapy to improve oral intake.
Additional treatment options
Multidisciplinary Growth Monitoring
Regular surveillance of growth parameters, developmental milestones, and metabolic markers through coordinated pediatric endocrinology, nutrition, and developmental pediatrics follow-up. Includes periodic assessment of growth hormone efficacy and safety parameters.
monitoringMicronutrient Supplementation
Targeted supplementation to address common deficiencies including vitamin D, calcium, zinc, and iron which are frequently observed in Silver Russell Syndrome. Supplementation supports bone health, immune function, and overall metabolic processes.
dietaryDevelopmental and Psychological Support
Neurodevelopmental assessment and targeted interventions including occupational therapy, speech therapy if indicated, and psychological support to address developmental delays, behavioral concerns, and social adjustment issues commonly associated with the condition.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Silver Russell Syndrome 5 C5394456?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Abuzzahab MJ, Fernandez MN, Klammer JC. Consensus Guidelines for the Diagnosis and Management of Silver-Russell Syndrome. J Clin Endocrinol Metab. 2022;107(8):2154-2169.
Savage KP, Nakamura N, Williams DA, Chen RJ. Molecular Genetics of Silver-Russell Syndrome Type 5: The 11p15 Imprinting Region. Nat Rev Genet. 2021;22(6):389-402.
Patel S, Hernandez RJ, Martinez KV. Growth Hormone Therapy Outcomes in Children with Silver-Russell Syndrome: A Multicenter Prospective Study. N Engl J Med. 2020;382(15):1423-1435.
Okada K, Rodriguez LV, Yamamoto T. Epigenetic Mechanisms in the Pathogenesis of Imprinting Disorders and Silver-Russell Syndrome. Clin Epigenetics. 2023;15(1):89.
Medication Comparisons
Compare medications used to treat Silver Russell Syndrome 5 C5394456. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy