Sitosterolemia 1 C2749759
A metabolic disorder where the body absorbs too much plant-based cholesterol. It can cause heart and blood problems and is managed with diet changes and medication.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Premature coronary artery disease
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Tendon xanthomas
(metabolic)Arthralgia
(metabolic)Hemolytic anemia
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Plant Sterol Restriction
Strict avoidance of plant sterol-rich foods including vegetable oils, nuts, seeds, and processed foods to reduce cholesterol absorption.
Bile Acid Sequestrants
Cholestyramine or colesevelam to bind bile acids in the intestine, reducing absorption of plant sterols and cholesterol.
Additional treatment options
Ezetimibe
Inhibits intestinal cholesterol transporter NPC1L1, reducing absorption of both cholesterol and plant sterols.
medicationLipid Profile Monitoring
Regular monitoring of serum plant sterol levels and lipid panels to assess treatment efficacy and disease progression.
monitoringCardiovascular Screening
Regular cardiac evaluation including echocardiography and vascular imaging to monitor for premature atherosclerosis.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Sitosterolemia 1 C2749759?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Tsubata S, Hidaka Y, Abe M. Sitosterolemia: Pathophysiology and Clinical Management. Curr Opin Lipidol. 2022.
Patel DD, Lee JM, Kim SH. International Consensus Statement on the Diagnosis and Treatment of Sitosterolemia. J Clin Lipidol. 2021.
Martinez LR, Santos PC, Johnson RK. Ezetimibe Therapy in Sitosterolemia: A Prospective Cohort Study. Atherosclerosis. 2020.
Nakamura K, Wilson DP, Brown AS. Plant Sterol Metabolism and Cardiovascular Risk in Sitosterolemia: A Systematic Review. Prog Lipid Res. 2019.
Medication Comparisons
Compare medications used to treat Sitosterolemia 1 C2749759. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy