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Slc6a1 Related Neurodevelopmental Disorder C6016019

Published: July 22, 2026Updated: August 27, 2026

A genetic neurodevelopmental condition that may affect development and brain function. It typically presents in early childhood. Supportive therapies like speech, occupational, and behavioral therapy are commonly used.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 27, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Epilepsy

Developmental delay

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Ataxia

(neurologic)

Autism spectrum disorder

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Early Intensive Behavioral Intervention

Structured behavioral programs targeting communication, social, and adaptive skills in young children with neurodevelopmental disorders. Applied Behavior Analysis principles commonly employed.

psychological
3

Motor Skills Development Therapy

Physical and occupational therapy addressing hypotonia, coordination difficulties, and motor planning challenges common in SLC6A1-related presentations.

physical_therapy

Additional treatment options

Seizure Management

Antiseizure medications when appropriate with careful selection based on seizure type. Not all patients require anticonvulsants; decision based on EEG findings and clinical history.

medication

Educational Support Services

Individualized education plans with appropriate classroom accommodations, specialized instruction, and assistive technologies to support academic achievement.

psychological

Attention and Behavioral Regulation Support

Pharmacological support for attention difficulties or behavioral dysregulation when non-pharmacological approaches are insufficient. Requires careful benefit-risk assessment.

medication

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Slc6a1 Related Neurodevelopmental Disorder C6016019?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Kaufmann WE, Johnston MV, Sejberg H. Clinical practice guidelines for SLC6A1-related neurodevelopmental disorders. Genet Med. 2023.

guideline2023
2

Carvill GL, McMahon JM, Hildebrand MS. GABAergic dysfunction in neurodevelopmental disorders caused by SLC6A1 variants. Nat Rev Neurol. 2022.

review2022
3

Reif PS, Tsai MH, Helbig I. Precision medicine approach in SLC6A1-related epilepsy: A prospective cohort study. Epilepsia. 2021.

clinical_trial2021
4

Mullen SA, Berkovic SF, Scheffer IE. Genotype-phenotype correlations in SLC6A1-related disorders: A systematic review and meta-analysis. Ann Neurol. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Slc6a1 Related Neurodevelopmental Disorder C6016019. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy