Small Intestinal Diffuse Large B Cell Lymphoma C3272522
An aggressive cancer of white blood cells developing in the small intestine. It may cause pain, bleeding, or obstruction. Treatment typically involves chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Gastrointestinal bleeding
Bowel obstruction
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Weight loss
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
R-CHOP Chemotherapy
Combination immunochemotherapy using rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone. This is the standard first-line treatment for diffuse large B-cell lymphoma, targeting cancer cells through multiple mechanisms.
Surgical Intervention
Surgical resection may be necessary for bowel obstruction, perforation, or diagnostic biopsy. Emergency surgery addresses life-threatening complications while definitive treatment is planned.
Additional treatment options
Radiation Therapy
Involved-field radiation therapy may be used for localized disease or as consolidation after chemotherapy in certain high-risk presentations. Particularly useful when disease is confined to a specific abdominal region.
procedureAutologous Stem Cell Transplant
High-dose chemotherapy followed by stem cell rescue is considered for patients with relapsed or refractory disease achieving good response to salvage therapy. This approach offers potential for long-term remission.
procedureSurveillance Imaging
Regular CT or PET-CT scans combined with clinical assessment monitor for disease response and detect relapse early. Typically performed every 3-6 months for the first 2 years following treatment completion.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Small Intestinal Diffuse Large B Cell Lymphoma C3272522?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zelenetz AD, Gordon LI, Abramson JS, et al. NCCN Guidelines Insights: B-Cell Lymphomas, Version 4.2021. J Natl Compr Canc Netw. 2021.
Salati M, Calabrese C, Ciani M, et al. Primary intestinal diffuse large B-cell lymphoma: a comprehensive review. Haematologica. 2022.
Kim SG, Kim SJ, Lee J, et al. Rituximab plus CHOP chemotherapy for primary intestinal diffuse large B-cell lymphoma: a multicenter phase II study. Ann Hematol. 2020.
Liu Y, Chen Q, Zhang W, et al. Surgical resection versus chemotherapy in primary intestinal DLBCL: a meta-analysis. Blood Adv. 2023.
Medication Comparisons
Compare medications used to treat Small Intestinal Diffuse Large B Cell Lymphoma C3272522. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy