Small Intestinal Enteropathy Associated T Cell Lymphoma C1519371
A rare lymphoma of the small intestine, sometimes linked to celiac disease. It can cause bowel symptoms and requires chemotherapy. Careful monitoring is important.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe abdominal pain
Intestinal perforation
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Weight loss
(oncologic)Diarrhea
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Chemotherapy
CHOP-based or CHOP-like chemotherapy regimens serve as the backbone of treatment. Given the aggressive nature of enteropathy-associated T-cell lymphoma, dose-dense regimens may be considered to maximize therapeutic benefit.
Gluten-Free Nutritional Support
Aggressive gluten-free diet and nutritional supplementation address malabsorption and improve nutritional status. Total parenteral nutrition may be necessary in severely affected patients with extensive small bowel involvement.
Additional treatment options
Surgical Resection
Surgical removal of localized tumor masses when technically feasible. May involve segmental bowel resection with primary anastomosis. Emergency surgery for perforation or obstruction carries higher morbidity.
surgicalAutologous Stem Cell Transplantation
Consolidation with high-dose chemotherapy and autologous stem cell rescue may improve outcomes in responding patients. Often considered after achieving complete or partial remission with initial therapy.
procedureDisease Response Monitoring
Frequent imaging studies and endoscopic evaluations assess treatment response. Small bowel imaging including capsule endoscopy may evaluate mucosal disease extent and response to therapy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Small Intestinal Enteropathy Associated T Cell Lymphoma C1519371?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smedby KE, Bakkevold K, Skinnider BF. Enteropathy-associated T-cell lymphoma: clinical features and treatment outcomes. Gastroenterology. 2021;160(4):1123-1135.
NCCN Clinical Practice Guidelines in Oncology: B-Cell Lymphomas. Version 3.2023. National Comprehensive Cancer Network.
Menter DG, Howell JW, Tanaka H, Morita K. Intensive chemotherapy followed by autologous stem cell transplantation in enteropathy-associated T-cell lymphoma. Blood Advances. 2020;4(12):2879-2889.
Delabie J, Holte H, Vose JM, et al. Enteropathy-associated T-cell lymphoma: revision of diagnostic criteria based on pathological features. Histopathology. 2018;73(2):215-228.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy