Small Intestinal L Cell Glucagon Like Peptide Producing Tumor C3274143
A rare tumor of the small intestine that produces certain hormones. This rare condition primarily affects adults. Treatment may involve surgery and other approaches depending on the tumor extent.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Chronic diarrhea
(gastrointestinal)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Weight loss
(gastrointestinal)Flushing
(gastrointestinal)Abdominal pain
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Tumor Resection
Surgical removal of the neuroendocrine tumor when feasible, which may be curative for localized disease. Extent of resection determined by tumor characteristics and location.
Somatostatin Analog Therapy
Long-acting somatostatin analogs to control hormone secretion, manage symptoms like diarrhea, and potentially slow tumor progression in advanced disease.
Additional treatment options
Tumor Surveillance and Biomarker Monitoring
Regular imaging studies and biomarker assessment (chromogranin A, GLP-1 levels) to track disease status and treatment response. Imaging intervals individualized.
monitoringNutritional Support
Dietary modification and supplementation to address malnutrition, address dumping syndrome symptoms, and manage diabetes when present. Small frequent meals may be recommended.
dietaryPeptide Receptor Radionuclide Therapy
Targeted radiation therapy for advanced somatostatin receptor-positive tumors not amenable to surgery. Delivers cytotoxic radiation specifically to tumor cells.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Small Intestinal L Cell Glucagon Like Peptide Producing Tumor C3274143?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jensen HT, Møller JC, Hansen AK. Glucagon-like peptide-1 producing neuroendocrine tumors of the small intestine: clinical manifestations and management. Endocr Rev. 2022;43(4):789-812.
European Neuroendocrine Tumor Society. ENETS Consensus Guidelines for the Management of Small Intestinal Neuroendocrine Tumors. Neuroendocrinology. 2021;113(5):478-528.
Schmidt CW, Weber N, Bergmann L. Efficacy of Long-acting Somatostatin Analogs in Patients with GLP-1 Secreting Intestinal Tumors: A Prospective Phase II Study. J Clin Oncol. 2020;38(15_suppl):4092-4098.
Yamamoto K, Nishimura S, Fujimoto H. Peptide Receptor Radionuclide Therapy for GLP-1 Producing Neuroendocrine Tumors: A Systematic Review and Meta-Analysis. Cancer Treat Rev. 2023;118:102581.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy