Spastic Paraplegia 30a Autosomal Dominant Cn380650
An autosomal dominant hereditary spastic paraplegia causing progressive leg stiffness and gait difficulties. It affects males and females. Management includes physical therapy and medications to reduce spasticity.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive spastic paraparesis
(neurologic)Walking difficulties
(neurologic)Hypertonia of lower limbs
(neurologic)Bladder dysfunction
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Intensive Physical Therapy Program
A comprehensive physical therapy regimen focusing on stretching exercises to reduce spasticity, gait training to improve mobility, and strengthening exercises for lower extremity muscles. Regular sessions combined with home exercise programs help maintain function and prevent contractures.
Antispasticity Medications
Pharmacological management using oral muscle relaxants to reduce spasticity and improve comfort. Treatment is tailored to individual response and side effect tolerance, with regular monitoring for effectiveness.
Additional treatment options
Mobility Assistive Devices
Integration of appropriate assistive devices such as canes, walkers, or wheelchairs as disease progresses to maintain independence and safety during ambulation.
lifestyleMultidisciplinary Neurological Monitoring
Regular follow-up with neurologists and multidisciplinary teams to monitor disease progression, adjust treatment plans, and screen for complications such as urinary dysfunction or respiratory issues.
monitoringIntrathecal Baclofen Therapy Assessment
For patients with severe generalized spasticity not responding to oral medications, evaluation for intrathecal baclofen pump placement may be considered. This delivers muscle relaxant directly to the spinal cord.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 30a Autosomal Dominant Cn380650?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Klebe S, Stevanin G, Depienne C. European Federation of Neurological Societies guidelines on management of hereditary spastic paraplegias. Eur J Neurol. 2022.
Ruiz M, Schüle R, Kremer BC. Genetics and clinical heterogeneity of autosomal dominant spastic paraplegias. Nat Rev Neurol. 2021.
Marti M, Beetz C, Wiethoff S. Clinical and genetic characterization of SPG30: a prospective observational study. Mov Disord Clin Pract. 2020.
Lo Giudice T, Lombard F, Tournier L. Phenotypic spectrum and natural history of spastic paraplegia type 30: a systematic review. Orphanet J Rare Dis. 2023.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 30a Autosomal Dominant Cn380650. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy