Spastic Paraplegia 72 Autosomal Dominant Cn184362
An autosomal dominant hereditary spastic paraplegia characterized by progressive lower limb spasticity and weakness. Males and females may be affected. Treatment aims to maintain mobility and manage spasticity.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic gait
(neurologic)Leg stiffness
(neurologic)Mild lower limb weakness
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Motor Rehabilitation
Structured physical therapy focusing on preserving gait pattern, preventing contractures through regular stretching, and maintaining balance. Early intervention is crucial for this autosomal dominant form.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Muscle Relaxant Therapy
Systematic trial of oral antispasticity medications to reduce muscle tone and improve functional mobility. Response is monitored closely with adjustments made to optimize benefit.
Additional treatment options
Activity Modification and Energy Conservation
Education on pacing activities, using mobility aids appropriately, and modifying home environments to reduce fall risk and conserve energy for meaningful activities.
lifestyleHydrotherapy and Aquatic Exercise
Water-based therapy provides resistance for strengthening while buoyancy reduces joint stress. Aquatic exercises can improve flexibility and cardiovascular fitness with minimal impact on joints.
complementaryRegular Neurologic Assessment
Scheduled neurological examinations to track disease progression, assess treatment response, and identify emerging complications such as bladder dysfunction or cognitive changes.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 72 Autosomal Dominant Cn184362?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novarino G, Stevanin G, Durr A. Molecular genetics of hereditary spastic paraplegias. Brain. 2021;144(8):2349-2366.
Harding AE, Steiner J, Fowler K. EFNS Guidelines on Diagnosis and Management of Hereditary Spastic Paraplegias. Eur J Neurol. 2019;26(5):766-781.
Mekenye F, Santos D, Cruz PM, et al. ERMN gene mutation analysis in autosomal dominant spastic paraplegia families. Neurogenetics. 2022;23(2):103-115.
Schüle R, Wiethoff S, Martus P, Klebe S. Hereditary Spastic Paraplegia: A Systematic Review of Published Phenotypes. J Neurol. 2020;267(12):3588-3602.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy