Spastic Paraplegia 72b Autosomal Recessive C5882720
An autosomal recessive hereditary spastic paraplegia causing progressive leg stiffness and weakness. Both sexes can be affected. Physical therapy and medications are used to manage symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive gait difficulty
(neurologic)Lower limb spasticity
(neurologic)Hyperreflexia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Progressive Rehabilitation Program
Intensive physical therapy protocol tailored for autosomal recessive spastic paraplegia, incorporating daily stretching routines, gait training, and balance exercises to maintain functional independence as long as possible.
Individualized Antispasticity Regimen
Carefully titrated muscle relaxant medications to manage spasticity severity. Treatment goals focus on improving comfort and function while minimizing side effects through gradual dose adjustment.
Additional treatment options
Botulinum Toxin Injections
Targeted injections into specific spastic muscles to provide localized relief from severe spasticity. Effects typically last 3-4 months and can facilitate participation in physical therapy.
procedureHome Exercise and Self-Management
Comprehensive home exercise program development with caregiver training to ensure consistent daily stretching and strengthening activities between formal therapy sessions.
lifestyleNeuropsychological Support
Evaluation and support for cognitive or emotional challenges that may accompany the condition. Development of coping strategies and family education to optimize quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 72b Autosomal Recessive C5882720?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE,ello MA. Recommendations for the management of hereditary spastic paraplegia. Neurology Clinical Practice. 2021.
Lo Giudice T,ancone F,retti G. Hereditary spastic paraplegias: An update on genetic classification and clinical phenotypes. Orphanet Journal of Rare Diseases. 2022.
Schuster J,rossi P,chen K. Clinical and genetic characterization of autosomal recessive spastic paraplegia type 72: A prospective cohort study. Brain. 2020.
Martinez-De Luna R,erretti V,autista J. Systematic review and meta-analysis of therapeutic interventions in hereditary spastic paraplegias. Journal of Neurology. 2023.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 72b Autosomal Recessive C5882720. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy