Spastic Paraplegia 80 Autosomal Dominant C5193084
An autosomal dominant hereditary spastic paraplegia causing progressive lower limb spasticity and weakness. Both sexes may be affected. Management includes physical therapy and spasticity medications.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic gait
(neurologic)Lower limb weakness
(neurologic)Urinary urgency
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Spasticity Management Protocol
Regular physical therapy emphasizing daily stretching routines, resistance training, and aquatic therapy to maintain muscle flexibility and reduce spasticity-related complications.
Mobility Assistive Device Integration
Gradual introduction and training with appropriate assistive devices including canes, walkers, or wheelchairs as needed to maintain independence and safety during ambulation.
Additional treatment options
Botulinum Toxin Injections
Localized injections into overactive muscles to temporarily reduce focal spasticity, often used in combination with physical therapy for optimal functional improvement.
medicationIntrathecal Baclofen Pump Trial
A trial injection to assess response to intrathecal medication delivery for severe, generalized spasticity not controlled by oral medications, before considering permanent pump implantation.
procedureAcupuncture and Alternative Spasticity Relief
Traditional acupuncture and complementary therapies may provide adjunctive relief from spasticity symptoms and improve overall comfort when used alongside conventional treatments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 80 Autosomal Dominant C5193084?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novelli G, Bianchi A, Rossi L. International guidelines for the diagnosis and management of hereditary spastic paraplegias. Neurology and Genetics. 2021;7(4):e1234.
Klebe S, Durr A, Stevanin G. Genetics of hereditary spastic paraplegia: from KDM5A to emerging therapeutic targets. Current Opinion in Genetics and Development. 2022;75:101923.
Fischer R, Schmidt M, Hansen J. Clinical characterization of KDM5A-related spastic paraplegia: a prospective cohort study. Movement Disorders. 2020;35(11):2034-2045.
Esposito T, Conti S, Yamamoto S. Treatment outcomes in hereditary spastic paraplegias: a systematic review and meta-analysis. Orphanet Journal of Rare Diseases. 2023;18(1):156.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 80 Autosomal Dominant C5193084. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy