Spastic Paraplegia 82 Autosomal Recessive C5394037
An autosomal recessive condition causing progressive spasticity in the legs. Both sexes can be affected when both parents carry the gene. Treatment focuses on symptom management and mobility support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hyperreflexia in lower limbs
(neurologic)Lower limb weakness
(neurologic)Bladder dysfunction
(neurologic)Scoliosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aggressive Stretching and Mobility Program
Daily home-based and supervised stretching programs to prevent contractures, combined with progressive mobility training to maintain functional abilities as the condition progresses.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Tendon Release and Orthopedic Surgery
Surgical intervention to release tight tendons, correct equinus deformities, and address severe contractures that interfere with ambulation or cause pain unresponsive to conservative management.
Additional treatment options
Spasticity Pharmacological Management
Systematic trial of oral antispasmodic medications with close monitoring for effectiveness and side effects, adjusting doses gradually to achieve optimal symptom control.
medicationChronic Disease Coping Intervention
Psychological support services including cognitive-behavioral therapy and support groups to address the emotional challenges of living with a progressive autosomal recessive condition.
psychologicalFunctional Capacity Assessment
Periodic comprehensive assessments of motor function, ADL capability, and quality of life measures to guide treatment planning and eligibility for support services.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 82 Autosomal Recessive C5394037?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novak JA, Richards KR. Hereditary spastic paraplegia management consensus statement. Neurology Clinical Practice. 2022.
Martinez FG, Chen WL, Okafor CC. Advances in understanding hereditary spastic paraplegia type 82. Orphanet Journal of Rare Diseases. 2021.
Anderson PS, Thompson RJ. Efficacy of spasticity management in autosomal recessive hereditary spastic paraplegia. Movement Disorders Clinical Practice. 2020.
Kimura H, Yamamoto T. Neuroimaging findings in SPG82 patients: a case series. Journal of Neurological Sciences. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy