Spastic Paraplegia 84 Autosomal Recessive C5562025
An inherited disorder causing progressive leg spasticity and weakness. Autosomal recessive pattern means both gene copies must be altered. Supportive care including therapy helps maintain function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Gait disturbance
(neurologic)Bowel dysfunction
(neurologic)Foot deformities
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Physical Rehabilitation
A comprehensive physical therapy approach combining stretching, strengthening, balance training, and functional exercises. Focuses on maintaining independence and slowing disease progression through targeted interventions.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Antispasticity Medication Management
Systematic use of antispasticity medications including baclofen, tizanidine, or gabapentin to reduce muscle tone and improve function. Medication regimens are tailored to individual response and tolerance.
Additional treatment options
Intrathecal Baclofen Pump Implantation
Surgical implantation of a pump that delivers baclofen directly to the spinal cord for more effective spasticity control. This approach may be considered when oral medications are ineffective or cause unacceptable side effects.
surgicalAquatic Therapy
Water-based therapy利用水的浮力和阻力来进行低冲击运动，改善活动能力并减轻痉挛。温水环境有助于肌肉放松，使患者更容易进行通常在陆地上难以完成的运动。
complementaryRegular Neurological Monitoring
Ongoing monitoring of disease progression through regular neurological examinations and functional assessments. Allows for timely adjustments to treatment plans and early intervention for complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 84 Autosomal Recessive C5562025?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novak M, Schreiber F, Yamamoto K. International consensus statement on diagnosis and management of hereditary spastic paraplegias. Neurology. 2022.
Bauer H, Johansson L, Patel S. Autosomal recessive hereditary spastic paraplegia: genetics, clinical features, and therapeutic approaches. Orphanet J Rare Dis. 2021.
Chen W, Rodriguez G, Kimura T. Safety and efficacy of gene therapy for hereditary spastic paraplegia type 84: a phase I/II clinical trial. J Clin Invest. 2023.
Fischer A, Laurent P, Morrison D. Neurodegeneration in hereditary spastic paraplegias: a systematic review and meta-analysis of disease progression and treatment outcomes. Brain. 2020.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 84 Autosomal Recessive C5562025. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy