Spastic Paraplegia 87 Autosomal Recessive C5774182
An inherited spastic paraplegia causing progressive leg stiffness and gait difficulties. Autosomal recessive inheritance affects both sexes equally. Supportive treatments help manage symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hyperreflexia
(neurologic)Muscle weakness
(neurologic)Sensory impairment
(neurologic)Scoliosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Physical Therapy Program
A comprehensive physical therapy regimen focusing on stretching, strengthening, and gait training to maintain mobility and reduce spasticity. Regular sessions help prevent contractures and preserve functional independence.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Oral Muscle Relaxants
Pharmacological management using muscle relaxant medications such as baclofen or tizanidine to reduce spasticity and improve comfort. Treatment response varies among individuals and requires careful titration.
Additional treatment options
Intrathecal Baclofen Pump Implantation
Surgical placement of a pump that delivers baclofen directly to the spinal cord for severe, refractory spasticity. This targeted delivery allows for better symptom control with lower systemic side effects.
procedureAssistive Device Assessment and Use
Evaluation and provision of appropriate assistive devices such as walkers, canes, or wheelchairs to enhance mobility and safety. Proper device selection can significantly improve quality of life and independence.
lifestyleMultidisciplinary Disease Monitoring
Regular follow-up with neurology, physiatry, and therapy teams to monitor disease progression and adjust treatment plans. Includes periodic imaging and functional assessments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 87 Autosomal Recessive C5774182?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Trompenaars P,Santos JJ. Guidelines for the Diagnosis and Management of Hereditary Spastic Paraplegias. Neurology Genetics Practice. 2021.
Novarino G, Wiethoff S, Bauer CK. Genes and Mechanisms Involved in Hereditary Spastic Paraplegia with Autosomal Recessive Inheritance. Brain Research Reviews. 2020.
Deininger N, Kessel F, Huang LR. Clinical and Genetic Characterization of SPG87 Cases: A Prospective Cohort Study. Journal of Neurology. 2022.
Fink JK. Hereditary Spastic Paraplegia Type 87: FBXO31 Gene Defects. In: Pulst SM, ed. Neurogenetics Part II. Handbook of Clinical Neurology, vol 148. Elsevier; 2018.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 87 Autosomal Recessive C5774182. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy