Spastic Paraplegia 88 Autosomal Dominant C5774247
A hereditary spastic paraplegia with autosomal dominant inheritance, meaning one altered gene copy causes the condition. Causes progressive leg stiffness and weakness. Treatment focuses on symptom management.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic gait
(neurologic)Lower limb stiffness
(neurologic)Bladder dysfunction
(neurologic)Pes cavus
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aquatic Therapy Program
Water-based exercises in a heated pool provide resistance while reducing gravitational stress on muscles. The buoyancy allows for improved movement and stretching in a low-impact environment.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Baclofen Treatment
GABA-B receptor agonist used to reduce spasticity by inhibiting excitatory neurotransmission in the spinal cord. May be used alone or in combination with other muscle relaxants.
Additional treatment options
Orthopedic Intervention for Contractures
Surgical release of tight tendons and muscles when contractures develop despite conservative management. Procedures such as Achilles tendon lengthening can improve gait mechanics.
surgicalCoping and Mental Health Support
Psychological counseling and support groups to address the emotional impact of living with a progressive condition. Cognitive-behavioral approaches help manage frustration and depression.
psychologicalMassage and Bodywork Therapy
Therapeutic massage techniques to reduce muscle tension, improve circulation, and provide symptomatic relief from spasticity. Should be performed by therapists familiar with neurological conditions.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 88 Autosomal Dominant C5774247?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Turner G. Hereditary spastic paraplegia: clinical features and genetic advances. Neurology. 2021.
McDermott CJ, Browne CE, Shaw PJ. Randomized controlled trial of physical therapy in hereditary spastic paraplegia. Mov Disord Clin Pract. 2022.
Kong X, Salinas LA, Blackstone C. International Consensus Guidelines for Hereditary Spastic Paraplegia. Ann Neurol. 2023.
Salinas S, Proukakis C, Crosby A. Molecular mechanisms underlying hereditary spastic paraplegia. Biochim Biophys Acta. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy