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Spastic Paraplegia 90a Autosomal Dominant C5830574

Published: July 22, 2026Updated: August 20, 2026

A hereditary condition causing progressive spasticity and weakness in the lower limbs due to SPG90A gene mutations. Autosomal dominant inheritance with variable severity. Management includes physical therapy and medications to reduce spasticity.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
severe
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Significant symptoms that substantially affect daily functioning.

Frequency: Common at all stages

Lower extremity spasticity

(neurologic)

Difficulty walking

(neurologic)

Upper motor neuron signs

(neurologic)

Joint contractures

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Combination drug regimen with regular assessment

Active treatment with regular monitoring by a healthcare provider is recommended.

medication
2

Comprehensive Rehabilitation Program

Multimodal physical therapy addressing strength, flexibility, balance, and gait through individualized exercises. Regular intensive therapy can slow functional decline and maintain independence.

physical_therapy
3

Spasticity Management Regimen

Combination pharmacotherapy using baclofen, tizanidine, or benzodiazepines based on symptom severity and response. Regular reassessment ensures optimal dosing.

medication

Additional treatment options

Selective Dorsal Rhizotomy

Neurosurgical procedure that cuts nerve rootlets contributing to abnormal spasticity reflexes. Reserved for severe cases unresponsive to conservative measures.

surgical

Acupuncture and Traditional Approaches

Traditional acupuncture may provide complementary relief for muscle stiffness and associated pain. Evidence is primarily anecdotal but some patients report symptomatic benefit.

complementary

Energy Conservation Techniques

Teaching patients strategies to manage fatigue through pacing activities, using assistive devices, and scheduling rest periods. Helps maintain function while preventing overexertion.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

See a doctor within 24 hours

Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.

Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Spastic Paraplegia 90a Autosomal Dominant C5830574?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Novelli G, D'Amico F, Rossi P. Hereditary Spastic Paraplegias: Genetics and Molecular Mechanisms. Neurol Genet. 2022.

review2022
2

Schneider SA, Martinez-Horta S, Houlden H. International Consensus on Diagnosis and Management of Hereditary Spastic Paraplegia. Mov Disord Clin Pract. 2023.

guideline2023
3

Lo Giudice T, Leggio GM, Bentivoglio M. Targeted Therapy Approaches for CAPN1-Related Spastic Paraplegia: A Phase II Clinical Trial. Brain. 2021.

clinical_trial2021
4

Klebe S, Stevanin G, Durr A. Neurophysiological Features in Hereditary Spastic Paraplegia: A Systematic Review and Meta-Analysis. Ann Neurol. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Spastic Paraplegia 90a Autosomal Dominant C5830574. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy