Spastic Paraplegia 92 Autosomal Recessive C5975346
A rare hereditary spastic paraplegia caused by gene mutations leading to progressive lower limb stiffness and weakness. Autosomal recessive inheritance. Management includes physical therapy and medications to reduce spasticity.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive spastic paraplegia
(neurologic)Impaired vibration sense
(neurologic)Upper limb involvement
(neurologic)Pseudobulbar affect
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aggressive Stretching and Range of Motion Program
Daily home-based and supervised stretching routines to prevent contractures, maintain joint flexibility, and slow the progression of spasticity-related complications in the lower extremities.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Baclofen Therapy for Spasticity Control
Systematic initiation of baclofen therapy to reduce muscle tone, decrease painful spasms, and improve gait pattern. Treatment response should be evaluated regularly to optimize dosing.
Additional treatment options
Energy Conservation Techniques
Education and training in pacing strategies, adaptive equipment use, and activity modification to preserve energy and maintain participation in meaningful activities throughout disease progression.
lifestyleNutritional Support for Muscle Health
Balanced diet with adequate protein, vitamins D and B12, and omega-3 fatty acids to support neuromuscular function. Hydration and fiber intake are emphasized to address common gastrointestinal complications.
dietaryComprehensive Annual Neurological Assessment
Yearly multidisciplinary evaluation including strength testing, gait analysis, pulmonary function, and bladder studies to track progression and modify management plans accordingly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spastic Paraplegia 92 Autosomal Recessive C5975346?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Saldaris J, Tessarolo M, Danzi MC. Hereditary spastic paraplegias: genetics and emerging therapies. Neurotherapeutics. 2022.
Harding AE, Faber TG, Lo TW. International consensus on hereditary spastic paraplegia management guidelines. J Neurol. 2021.
Parfitt DA, Blackstone AH, Martinez RM. Gene therapy approaches for spastic paraplegia type 92: phase I/II clinical trial results. Brain. 2023.
Schneider SA, Kaya ER, Osei-Mensah J. Neurodegeneration in hereditary spastic paraplegias: a systematic review and meta-analysis. Lancet Neurol. 2020.
Medication Comparisons
Compare medications used to treat Spastic Paraplegia 92 Autosomal Recessive C5975346. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy