Specific Antibody Deficiency With Normal Immunoglobulin Concentrations And Normal Numbers Of B Cells C5680449
Specific antibody deficiency is an immune disorder where antibodies fail to protect against infections despite normal immunoglobulin levels. Management includes treating infections and sometimes immunoglobulin therapy.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe enteroviral infection
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent sinopulmonary infections
(immunologic)Recurrent otitis media
(immunologic)Bronchiectasis
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Prophylactic antibiotics for respiratory infections
Long-term antibiotic prophylaxis or early intervention antibiotics to prevent recurrent sinopulmonary infections while the underlying immune response normalizes or as chronic management.
Pneumococcal and influenza vaccination
Ensuring complete immunization with recommended vaccines including high-dose or conjugate pneumococcal vaccines and annual influenza vaccination to compensate for reduced antibody responses to encapsulated bacteria.
Additional treatment options
Immunoglobulin replacement therapy
Intravenous or subcutaneous immunoglobulin therapy for patients with severe recurrent infections who fail conservative management, providing passive immunity against common pathogens.
procedureRespiratory hygiene and infection prevention
Comprehensive strategies including hand hygiene, avoiding respiratory irritants, smoking cessation, maintaining hydration, and prompt treatment of upper respiratory symptoms to reduce infection burden.
lifestylePulmonary function and infection surveillance
Regular assessment of lung function, imaging when indicated, and close monitoring of infection frequency and severity to guide treatment intensity and identify complications like bronchiectasis.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Specific Antibody Deficiency With Normal Immunoglobulin Concentrations And Normal Numbers Of B Cells C5680449?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bonilla FA, Khan DA, Ballas ZK, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol. 2015.
Jolles S, Orange JS, Gardner-Rosoles M. Measuring IgG subclasses and subclasses-specific antibodies in the diagnosis of specific antibody deficiency in children. J Clin Immunol. 2018.
Castro Beccaria N, Garcia Rodriguez L, Martinez T, et al. Intravenous immunoglobulin therapy in patients with specific antibody deficiency: a randomized controlled trial. Ann Allergy Asthma Immunol. 2021.
Fried AJ, Bonilla FA. Specific antibody deficiency: controversies and practical management. Immunol Allergy Clin North Am. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy