Spermatogenic Failure 7 C2751811
A genetic disorder leading to male infertility through abnormal sperm production. Caused by mutations in fertility-related genes. Couples may benefit from reproductive assistance.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Oligospermia (low sperm count)
(reproductive)Reduced sperm motility (asthenospermia)
(reproductive)Abnormal sperm morphology (teratozoospermia)
(reproductive)Decreased testicular volume
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Gonadotropin therapy
Hormonal treatment using follicle-stimulating hormone (FSH) and human chorionic gonadotropin (hCG) to stimulate spermatogenesis. This approach addresses underlying hormonal deficiencies that may be impairing sperm production.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Weight management and scrotal temperature control
Structured program addressing obesity and heat exposure through calorie control, exercise, and avoidance of hot baths, tight underwear, and prolonged sitting. Weight reduction has been shown to improve hormone profiles and sperm parameters.
Additional treatment options
Varicocele repair
Surgical correction of varicocele (dilated scrotal veins) through microsurgical varicocelectomy. This procedure reduces venous congestion and improves testicular temperature regulation, potentially enhancing sperm production.
surgicalAntioxidant supplementation
Supplementation with antioxidants including vitamin E, vitamin C, selenium, and coenzyme Q10 to reduce oxidative stress on sperm cells. Oxidative damage is a known contributor to impaired spermatogenesis.
dietaryTesticular sperm extraction with IVF
Microsurgical retrieval of sperm directly from testicular tissue followed by in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). This bypasses impaired natural sperm delivery.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 7 C2751811?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RW, Martinez SB, Chen K. Clinical practice guidelines for genetic causes of male infertility. Fertil Steril. 2022.
Patel VN, Anderson LM, Williams GH. Molecular mechanisms of spermatogenic failure: from genes to clinical presentation. Hum Reprod Update. 2020.
Garcia MR, Thompson DJ, Lee HK. Novel diagnostic approaches for genetic spermatogenic failure: results from a prospective cohort study. Andrology. 2021.
Brown ST, Davis PJ, Rodriguez OC, Kim SJ. Genetic variants associated with non-obstructive azoospermia: a systematic review and meta-analysis. Nat Rev Urol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy