Spermatogenic Failure 72 C5676980
A genetic disorder causing male infertility due to defective sperm development. It stems from specific genetic mutations. Treatment focuses on reproductive assistance.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Azoospermia (absence of sperm in ejaculate)
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Non‑obstructive azoospermia
(reproductive)Small testes volume
(reproductive)Elevated luteinizing hormone (LH)
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Human menopausal gonadotropin injection therapy
Combination of FSH and LH hormones administered via subcutaneous injection to directly stimulate testicular germ cells. This bypasses pituitary dysfunction and directly supports spermatogenic activity.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Sleep optimization and circadian rhythm regulation
Structured sleep hygiene program targeting 7-9 hours of quality sleep with consistent timing. Sleep disruption impairs nocturnal testosterone surges and disrupts the hypothalamic-pituitary-gonadal axis.
Additional treatment options
Traditional Chinese Medicine herbal formulation
Individualized herbal medicine based on Traditional Chinese Medicine principles, often incorporating ingredients such as Tribulus terrestris, Cuscuta chinensis, and Epimedium. Used to address kidney yang deficiency patterns in male infertility.
complementaryL-carnitine and acetyl-L-carnitine supplementation
Amino acid supplementation supporting sperm energy metabolism and motility. Carnitine serves as a crucial energy substrate for sperm flagellar function and sperm cell maturation in the epididymis.
dietaryComprehensive assisted reproductive technology evaluation
Full evaluation for IVF/ICSI including genetic testing (karyotype, Y-chromosome microdeletions), infectious disease screening, and ovarian stimulation planning for partner. This determines feasibility and informs success probabilities.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 72 C5676980?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American Urological Association, American Society for Reproductive Medicine. Guidelines for the evaluation and management of male factor infertility. Fertil Steril. 2022.
Krausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol. 2021.
Tüttelmann F, Ruckert C, Röpke A. Clinical characteristics and genetic findings in patients with spermatogenic failure. Andrology. 2020.
Hwang K, Smith JF, Coward RM. Genetic testing for non-obstructive azoospermia: a systematic review. Eur Urol. 2023.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 72 C5676980. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy