Spermatogenic Failure 73 C5676988
A genetic condition causing male infertility through problems with sperm production. It involves mutations in genes needed for normal sperm development. Fertility specialists can advise on options.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility (primary)
(reproductive)Abnormal semen analysis (low count, motility, morphology)
(reproductive)Reduced testosterone levels
(reproductive)Gynecomastia (rare manifestation)
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hormonal Therapy with Clomiphene Citrate
Clomiphene citrate acts as an estrogen antagonist to increase gonadotropin release, stimulating spermatogenesis. Regular monitoring of hormone levels and sperm parameters is required throughout treatment.
Environmental Toxin Avoidance
Identification and elimination of exposure to endocrine-disrupting chemicals, heavy metals, and excessive heat sources. Includes avoiding saunas, hot tubs, tight underwear, and prolonged sitting.
Additional treatment options
Antioxidant Supplementation
Comprehensive antioxidant regimen including vitamin E, vitamin C, selenium, and coenzyme Q10 to reduce oxidative stress on sperm DNA. Dietary sources such as nuts, seeds, and leafy greens are encouraged.
dietaryVaricocele Repair
Surgical correction of palpable varicoceles using microsurgical subinguinal approach when clinical varicocele is present. This improves testicular blood flow and can enhance sperm production.
surgicalTesticular Sperm Extraction with IVF/ICSI
Advanced assisted reproductive technology involving surgical sperm retrieval when natural conception fails. Intracytoplasmic sperm injection enables fertilization with minimal sperm requirements.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 73 C5676988?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Alvarez JG, Tournaye H, Vogt PH. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2022.
Krausz C, Rajpert-De Meyts E, Gromoll J. Multicenter Trial on Genetic Causes of Non-Obstructive Azoospermia. Andrology. 2021.
Tüttelmann F, Wyrwoll MJ, Riera-Escamilla A. Genetics of Spermatogenic Failure: Current Knowledge and Clinical Implications. Nat Rev Urol. 2023.
Xie C, Sun Y, Liu Q. Gene Mutations in Spermatogenic Failure: A Systematic Review and Meta-Analysis. Hum Reprod Update. 2020.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 73 C5676988. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy