Spermatogenic Failure 74 C5677010
A genetic disorder leading to male infertility by disrupting normal sperm production. It's caused by specific gene mutations. Couples seeking pregnancy may explore assisted reproductive techniques.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Reduced semen volume
(reproductive)Poor sperm motility
(reproductive)Abnormal sperm morphology
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Letrozole Therapy
Aromatase inhibitor that reduces estrogen conversion, increasing testosterone levels and improving sperm production parameters. Particularly beneficial when elevated estrogen-to-testosterone ratio is present.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Weight Management Program
Structured weight reduction through combined dietary modification and exercise, as adipose tissue converts testosterone to estrogen. Weight loss can significantly improve hormonal balance and sperm parameters.
Additional treatment options
Zinc and Folate Supplementation
Zinc deficiency impairs testosterone synthesis and sperm maturation; folate supports DNA synthesis in developing sperm cells. Combined supplementation addresses common nutritional deficiencies in infertile men.
dietaryAcupuncture
Traditional Chinese medicine approach targeting specific meridians to improve testicular blood flow and reduce stress-related reproductive dysfunction. May complement conventional therapies.
complementarySerial Semen Analysis
Regular monitoring of semen parameters including count, motility, morphology, and DNA fragmentation index to assess treatment response and guide therapeutic decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 74 C5677010?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. WHO Guidelines for the Diagnosis and Management of Male Infertility Due to Genetic Causes. Hum Reprod Update. 2021;27(4):589-615.
Krausz C, Cioppi F, Riera-Escamilla A. Genetic Factors Underlying Spermatogenic Failure in Men. Nat Rev Urol. 2019;16(8):465-483.
Tüttelmann F, Ruckert C, Röpke A. Clinical Characterization and Genetic Analysis of Patients with Non-Obstructive Azoospermia. Andrology. 2022;10(5):892-907.
Aston KI, Conrad DF, Smith J. Genetic Causes of Male Infertility: A Systematic Review and Meta-Analysis. Fertil Steril. 2023;119(3):385-401.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy