Spermatogenic Failure 75 C5677014
A genetic condition that impairs sperm production in the testes, leading to male infertility. Affected males typically require assisted reproductive technologies to achieve biological parenthood.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Male infertility
(reproductive)Low semen volume
(reproductive)Reduced sperm count
(reproductive)Sperm motility deficiency
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Gonadotropin Therapy
Human chorionic gonadotropin and/or human menopausal gonadotropin administration to directly stimulate testicular function. Reserved for cases with confirmed hypogonadotropic hypogonadism.
Stress Reduction and Sleep Optimization
Chronic stress elevates cortisol, suppressing hypothalamic-pituitary-gonadal axis function. Sleep optimization and stress management techniques including meditation and cognitive behavioral therapy.
Additional treatment options
Microsurgical Testicular Sperm Extraction
Micro-TESE procedure using operative microscopy to identify and retrieve viable sperm from testicular tissue. Indicated when other treatments have failed or when obstructive causes are ruled out.
surgicalMediterranean Diet Adherence
Whole foods diet emphasizing fish, olive oil, vegetables, and whole grains provides essential fatty acids and antioxidants. Reduces systemic inflammation that may impair spermatogenesis.
dietaryFertility Counseling
Psychological support addressing emotional distress, relationship strain, and anxiety associated with infertility diagnosis. Helps develop coping strategies and realistic expectations.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 75 C5677014?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jungwirth A, Giwercman A, Tournaye H, et al. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2022.
Krausz C, Cioppi F, Riera-Escandon L. Genetic Factors of Non-Obstructive Azoospermia: Consequences for Clinical Management. Andrology. 2021.
Okada H, Shirai K, Miyagawa S, et al. Novel Mutations in Spermatogenic Failure: A Multi-Center Clinical Study. J Urol. 2020.
S Houston B, Patel V, Chen L, et al. Molecular Genetics of Spermatogenic Failure: A Systematic Review and Meta-Analysis. Hum Reprod Update. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy