Spermatogenic Failure 78 C5774276
A genetic condition where sperm production is significantly reduced or absent, causing male infertility. Family planning typically involves consulting fertility specialists about available options.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Male factor infertility
(reproductive)Oligospermia
(reproductive)Asthenozoospermia
(reproductive)Necrospermia
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Letrozole Aromatase Inhibitor Therapy
Letrozole inhibits aromatase enzyme to reduce estrogen and increase testosterone levels, promoting improved spermatogenesis in men with elevated estrogen.
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Testicular Sperm Extraction (TESE)
Microdissection TESE procedure to retrieve viable sperm directly from testicular tissue for use in assisted reproductive technologies when natural conception is not possible.
Additional treatment options
Smoking Cessation Program
Structured smoking cessation including behavioral counseling and nicotine replacement therapy to eliminate tobacco's harmful effects on sperm DNA and production.
lifestyleZinc and Selenium Supplementation
Targeted micronutrient supplementation with zinc and selenium essential for spermatogenesis and sperm maturation processes.
dietarySerial Semen Analysis and Hormone Monitoring
Regular monitoring of semen parameters and hormonal profile every 2-3 months to assess treatment response and guide therapeutic adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 78 C5774276?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jungwirth A, Diemer T, Kopa Z, et al. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2022.
Krausz C, Riera-Escamilla A, Moreno-Mendoza D. Genetic Causes of Non-Obstructive Azoospermia: A Narrative Review. Andrology. 2023.
Tuttelmann F, Ruckstock S, Behre HM. Clinical Characterization and Genetic Analysis of Men with Spermatogenic Failure. Hum Reprod. 2021.
Ghorbani M, Sadighi Gilani MA, Sabbaghian M. Genetic Mutations in Spermatogenic Failure: A Systematic Review and Meta-Analysis. Fertil Steril. 2020.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 78 C5774276. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy