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Spermatogenic Failure 8 C3151406

Published: July 22, 2026Updated: August 20, 2026

This genetic condition impairs the testes' capacity to generate healthy sperm, resulting in male infertility. Treatment involves working with fertility specialists to explore reproductive options.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q55.9
ICD-11
LA00.0
Body system
reproductive
Severity
severe
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(reproductive)

Significant symptoms that substantially affect daily functioning.

Frequency: Common at all stages

Infertility

(reproductive)

Low semen volume

(reproductive)

Decreased libido

(reproductive)

Testicular atrophy

(reproductive)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Microsurgical Varicocelectomy

Microsurgical repair of clinical varicocele using inguinal or subinguinal approach with optical magnification to minimize complications and optimize outcomes.

surgical
2

Combination drug regimen with regular assessment

Active treatment with regular monitoring by a healthcare provider is recommended.

medication
3

Human Chorionic Gonadotropin (hCG) Therapy

hCG administration to stimulate Leydig cell testosterone production and support spermatogenesis through LH-like activity.

medication

Additional treatment options

Environmental Toxin Avoidance

Identification and elimination of environmental exposures including pesticides, heavy metals, endocrine disruptors, and industrial chemicals that may impair spermatogenesis.

lifestyle

Pelvic Floor Physical Therapy

Specialized physical therapy targeting pelvic floor muscle function to potentially improve ejaculatory function and semen parameters.

physical_therapy

Intracytoplasmic Sperm Injection (ICSI)

Advanced assisted reproductive technology using single sperm injection directly into oocyte for fertilization when severe male factor is present.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

See a doctor within 24 hours

Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.

Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Spermatogenic Failure 8 C3151406?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Krausz C, Riera-Escamilla A. Genetics of male infertility: from chromosomal abnormalities to gene mutations. Minerva Med. 2021.

review2021
2

Jungwirth A, Giwereman A, Tournaye H, et al. European Association of Urology guidelines on male infertility. Eur Urol. 2022.

guideline2022
3

Ben Khelifa M, Coutton C, Zouari R, et al. Mutations in DNAH1, encoding an axonemal outer dynein arm heavy chain, cause primary ciliary dyskinesia and male infertility. Am J Hum Genet. 2014.

clinical_trial2014
4

Miyamoto T, Tsujimura A, Miyagawa Y, et al. Genetic causes and management of male infertility: a systematic review. Andrology. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Spermatogenic Failure 8 C3151406. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy