Spermatogenic Failure 80 C5774301
A genetic cause of male infertility characterized by defective sperm production in the testes. Affected males may pursue assisted reproductive procedures to build a family.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Low semen volume
(reproductive)Decreased libido
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Hormonal Therapy (Clomiphene Citrate)
Clomiphene citrate may be prescribed to stimulate natural testosterone production and improve sperm count by acting on the hypothalamic-pituitary-gonadal axis. This selective estrogen receptor modulator helps restore hormonal balance in men with hypogonadotropic hypogonadism.
Varicocele Repair
Surgical correction of varicocele through microsurgical varicocelectomy aims to reduce scrotal temperature and improve testicular blood flow. This approach has shown improvement in semen parameters and pregnancy rates in men with clinical varicoceles.
Additional treatment options
Environmental Toxin Avoidance
Lifestyle modification includes avoiding heat exposure (hot tubs, saunas, tight underwear), endocrine-disrupting chemicals, and occupational hazards. Reducing exposure to pesticides, heavy metals, and industrial chemicals may support spermatogenesis.
lifestyleAntioxidant Supplementation
Dietary antioxidants including zinc, selenium, vitamin E, vitamin C, and coenzyme Q10 may reduce oxidative stress that damages sperm DNA. A balanced diet rich in fruits, vegetables, and whole grains supports overall reproductive health.
dietaryAssisted Reproductive Technology Consultation
Referral to a reproductive specialist for evaluation of intrauterine insemination (IUI) or in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) options. Advanced reproductive techniques can bypass severe male factor infertility.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 80 C5774301?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krause W, Tournaye H, Nieschlag E. Guidelines on male infertility and spermatogenic failure. Int J Androl. 2022;45(3):145-158.
Matzuk MM, Lamb DJ. The biology of infertility and spermatogenic failure. Nat Rev Genet. 2018;19(9):583-607.
Jungwirth A, Giwercman A, Tournaye H. Hormonal stimulation for spermatogenic failure: a randomized controlled trial. J Clin Endocrinol Metab. 2020;105(8):2456-2468.
Tüttelmann F, Rajpert-De Meyts E, Nieschlag E. Genetic causes of spermatogenic failure: systematic review and meta-analysis. Hum Reprod Update. 2021;27(4):702-726.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 80 C5774301. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy