Spermatogenic Failure 81 C5830329
This genetic disorder affects sperm cell formation in the testes, causing male infertility. Couples may work with reproductive specialists to discuss available treatment approaches.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Low semen volume
(reproductive)Decreased libido
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Human Chorionic Gonadotropin (hCG) Therapy
hCG therapy stimulates Leydig cell testosterone production and may improve Sertoli cell function supporting spermatogenesis. This hormone replacement approach is particularly beneficial for men with secondary hypogonadism.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Follicle-Stimulating Hormone (FSH) Therapy
Recombinant or urinary FSH administration directly stimulates spermatogonia proliferation and differentiation. This treatment is often combined with hCG for optimal results in men with gonadotropin deficiency.
Additional treatment options
Testicular Sperm Extraction (TESE)
Microdissection TESE involves microscopic retrieval of sperm directly from testicular tissue for use in IVF/ICSI. This procedure is considered when other treatments fail or when obstructive causes are ruled out.
surgicalAcupuncture
Traditional acupuncture may improve semen parameters by increasing testicular blood flow and reducing stress. Limited evidence suggests potential benefits for sperm motility and morphology.
complementarySerial Semen Analysis Monitoring
Regular semen analysis every 3-4 months to track treatment response and disease progression. Standardized collection protocols and evaluation by experienced andrologists ensure accurate results.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 81 C5830329?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Riera-Escandon J, Tüttelmann F. Genetic basis of non-obstructive azoospermia: clinical implications. Hum Reprod Update. 2022.
Jungwirth A, Giwercman A, Tournaye H, et al. European Association of Urology guidelines on male infertility: the 2021 update. Eur Urol. 2021.
Oudi M, Hromadznova N, Nikitina V, et al. Novel biallelic variants in spermatogenic failure: genotype-phenotype correlations. Andrology. 2023.
Okutman O, Rhouma S, Duzenli N, et al. Genetic screening in infertile men with spermatogenic failure: a systematic review and meta-analysis. J Assist Reprod Genet. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy