Spermatogenic Failure 90 C5935587
A genetic form of male infertility where the testes cannot produce viable sperm. Treatment options may include assisted reproduction using donor sperm or adoption.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Infertility
(reproductive)Decreased libido
(reproductive)Poor semen quality
(reproductive)Scrotal discomfort
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combined Gonadotropin Therapy
Combination therapy using human menopausal gonadotropin (hMG) with FSH to directly stimulate spermatogenesis. Reserved for cases with confirmed gonadotropin deficiency.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Scrotal Heat Reduction
Behavioral modifications to reduce scrotal temperature including avoiding saunas, hot baths, laptop use on lap, and prolonged sitting. Essential for optimizing sperm production.
Additional treatment options
Conventional TESE
Open testicular sperm extraction performed under microscopy to locate focal areas of active spermatogenesis. More invasive than microTESE but allows larger tissue sampling.
surgicalL-Carnitine Supplementation
Amino acid supplementation supporting mitochondrial energy metabolism in sperm cells and testicular tissue. May improve sperm motility and count.
dietaryHormonal Panel Monitoring
Regular assessment of serum testosterone, FSH, LH, and estradiol levels to guide treatment adjustments and evaluate endocrine function.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 90 C5935587?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jungwirth A, Giwercman A, Tournaye H, et al. European Association of Urology guidelines on male infertility: the 2021 update. Eur Urol. 2021;79(5):721-731.
Tremellen K, Miari G, Frogett D. Understanding the pathogenesis of spermatogenic failure: a clinical perspective. Andrology. 2022;10(3):421-438.
Showell MG, Mackenzie-Proctor R, Brown J, et al. Antioxidants for male subfertility. Cochrane Database Syst Rev. 2020;8:CD007411.
Conrad M, Kant V, Goyal RK. Randomized controlled trial of recombinant FSH therapy in men with spermatogenic failure: efficacy and safety outcomes. J Clin Endocrinol Metab. 2019;104(11):5013-5025.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 90 C5935587. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy