Spermatogenic Failure 95 C5975347
A genetic disorder causing failure of sperm production, leading to male infertility. This severe condition typically requires assisted reproduction or alternative approaches.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spermatogenic arrest
(reproductive)Semen pH abnormality
(reproductive)Increased seminal fructose levels
(reproductive)Ejaculatory pain
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Clomiphene Citrate Therapy
Selective estrogen receptor modulator that stimulates gonadotropin release, enhancing testosterone production and spermatogenesis in men with hypogonadotropic hypogonadism.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Microscopic Varicocelectomy
Microsurgical repair of varicoceles using an inguinal or subinguinal approach, which improves testicular blood flow and can restore or enhance sperm production over time.
Additional treatment options
Environmental Toxin Avoidance
Systematic elimination of exposure to endocrine-disrupting chemicals, excessive heat, radiation, and industrial solvents that can impair germ cell development.
lifestyleAntioxidant Supplementation
Combined supplementation with vitamins C, E, selenium, zinc, and coenzyme Q10 to reduce oxidative stress in the testicular environment and protect developing sperm cells.
dietaryIntracytoplasmic Sperm Injection (ICSI)
Advanced reproductive technology where a single sperm is directly injected into an egg, bypassing impaired natural fertilization in men with severe male factor infertility.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 95 C5975347?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Riera-Escamilla A. Genetics of male infertility: from research to clinical practice. Hum Reprod Update. 2022.
Jungwirth A, Giwereman A, Krausz C, et al. European Association of Urology Guidelines on Male Infertility. Eur Urol. 2021.
Tüttelmann F, Ruckert N, Röpke A. Disorders of spermatogenesis: perspectives for novel genetic diagnostics. Mol Hum Reprod. 2018.
Arakawa T, Nakai M, Ishikawa H. Genetic mutations in non-obstructive azoospermia: a systematic review and meta-analysis. J Assist Reprod Genet. 2020.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 95 C5975347. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy