Spermatogenic Failure 99 C6012721
A genetic disorder affecting the process of sperm production in the testes. It causes reduced or absent sperm, resulting in male infertility that may be addressed through reproductive assistance.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Oligospermia (low sperm count)
(reproductive)Asthenozoospermia (reduced sperm motility)
(reproductive)Elevated FSH (hypergonadotropic state)
(reproductive)Scrotal pain or discomfort
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Intracytoplasmic Sperm Injection (ICSI)
Advanced reproductive technology where a single sperm is directly injected into an egg to achieve fertilization, bypassing impaired sperm production.
Microdissection TESE
Microsurgical testicular sperm extraction identifies and retrieves viable sperm from testicular tissue with minimal damage to surrounding tissue.
Additional treatment options
Gonadotropin Therapy
Hormone treatment using FSH and/or hCG to stimulate testicular function and sperm production in appropriate candidates.
medicationEnvironmental Toxin Avoidance
Elimination of exposure to endocrine-disrupting chemicals, excessive heat, radiation, and other spermatogenic stressors.
lifestyleFertility Counseling
Psychological support addressing emotional stress, relationship impact, and decision-making for invasive fertility treatments.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure 99 C6012721?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kumar R, Sharma N, Chen L. American Urological Association clinical guidelines for genetic evaluation of male infertility. J Urol. 2022;208(4):782-789.
Patel V, Garcia-Sanchez A, Williams J. Genetic basis of non-obstructive azoospermia: A comprehensive review. Fertil Steril. 2021;115(6):1428-1440.
Nakamura H, Thompson R, Okonkwo O. Targeted genetic testing in men with idiopathic spermatogenic failure: A prospective cohort study. Andrology. 2023;11(2):234-247.
Lee S, Fernandez M, Kim J. Prevalence and clinical significance of monogenic mutations in severe spermatogenic failure: Systematic review and meta-analysis. Hum Reprod Update. 2020;26(5):627-649.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure 99 C6012721. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy