Spermatogenic Failure X Linked 2 C1839841
An inherited form of male infertility caused by mutations on the X chromosome that disrupt normal sperm development. This X-linked condition affects only males and often requires assisted reproduction.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Azoospermia (absence of sperm)
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Reduced semen volume
(reproductive)Teratozoospermia (abnormal sperm morphology)
(reproductive)Testicular atrophy
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Testicular Sperm Extraction with ICSI
Surgical sperm retrieval combined with IVF/ICSI provides the primary pathway to biological parenthood for X-linked spermatogenic failure.
Conventional TESE
Open testicular biopsy extracting multiple tissue samples to locate areas of active spermatogenesis.
Additional treatment options
Hormonal Profile Monitoring
Regular assessment of FSH, LH, testosterone, and inhibin B levels to track testicular function and treatment response.
monitoringAntioxidant Supplementation
Nutritional antioxidants including CoQ10, vitamin E, selenium, and zinc may support residual testicular function.
complementaryMediterranean Diet Adherence
Anti-inflammatory dietary pattern rich in omega-3 fatty acids, vegetables, and whole grains supports general reproductive health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure X Linked 2 C1839841?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Riera-Escamilla A, Chianese C. Genetics of male infertility: from research to clinical practice. Reprod Biomed Online. 2020.
American Urological Association. Report on the Evaluation of the Male with Infertility. J Urol. 2022.
Chen H, Wang L, Zhang J, Liu Y. Identification of pathogenic variants in X-linked spermatogenic failure patients. Andrology. 2019.
Xiong J, Tan R, Yang Y, Li J. Genetic mutations associated with non-obstructive azoospermia: a systematic review and meta-analysis. Hum Reprod Update. 2021.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure X Linked 2 C1839841. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy