Spermatogenic Failure X Linked 3 C5542347
A genetic condition linked to the X chromosome that impairs sperm production in males. It leads to infertility, and treatment typically involves assisted reproductive technologies.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Oligospermia (low sperm count)
(reproductive)Asthenozoospermia (reduced sperm motility)
(reproductive)Elevated FSH (hypergonadotropic state)
(reproductive)Erectile dysfunction
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Microscopic Testicular Sperm Extraction
High-magnification microsurgery identifies scattered focal spermatogenesis within testes, maximizing retrieval success rates.
Empirical Clomiphene Citrate
Selective estrogen receptor modulator stimulating endogenous FSH release to potentially improve spermatogenesis.
Additional treatment options
Scrotal Heat Reduction
Avoidance of hot tubs, saunas, tight underwear, and prolonged sitting to maintain optimal testicular temperature.
lifestyleGenetic Inheritance Counseling
Specialized counseling explaining X-linked inheritance patterns and family planning implications.
psychologicalSerial Semen Analysis
Regular quantitative semen analysis tracking sperm concentration, motility, and morphology over time.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure X Linked 3 C5542347?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
World Health Organization. WHO Guidelines on Male Infertility and Genetic Disorders. Hum Reprod Update. 2021.
Krausz C, Chianese C. Genetic Basis of Male Infertility: X-linked Genes and Beyond. Andrology. 2020.
Van der Auwera GA, Oates RD. Clinical Outcomes of Microsurgical Reconstruction in Men with Non-Obstructive Azoospermia. Fertil Steril. 2019.
Ramaseshan N, Schlegel PN, Kaster J. Efficacy of Surgical Sperm Retrieval in Men with Genetic Causes of Azoospermia: A Systematic Review. Eur Urol. 2022.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure X Linked 3 C5542347. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy