Spermatogenic Failure X Linked 8 C5935568
An X-linked genetic disorder affecting sperm production in males, leading to impaired fertility. Diagnosis involves genetic testing and reproductive assessment. Family genetic counseling is recommended.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Male infertility
(reproductive)Low sperm count
(reproductive)Reduced semen ejaculation
(reproductive)Hypogonadism
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Micro-TESE with Fresh Sperm Use
Advanced microsurgical sperm extraction optimized for immediate use with fresh IVF-ICSI cycles. The surgical team coordinates directly with embryology lab to maximize sperm viability.
Human Chorionic Gonadotropin (hCG) Therapy
Exogenous hCG administration to stimulate testicular testosterone production and potentially support residual spermatogenesis. Often combined with FSH for enhanced effect.
Additional treatment options
Preimplantation Genetic Testing (PGT)
Genetic screening of embryos created through IVF-ICSI to identify those without the X-linked mutation. Allows selection of unaffected embryos for transfer.
procedureZinc and Selenium Supplementation
Targeted mineral supplementation to support sperm production and function. Zinc plays critical roles in testicular development and testosterone metabolism; selenium supports sperm motility.
dietaryComprehensive Fertility Assessment Protocol
Thorough evaluation including repeat semen analyses, hormone panels, genetic testing confirmation, and imaging studies to fully characterize fertility potential and guide treatment recommendations.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure X Linked 8 C5935568?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Tüttelmann F, Kliesch S. EAA/EMQN Best Practice Guidelines for Molecular Diagnosis of Y-Chromosome Microdeletions and Sporadic Spermatogenic Failure. Andrology. 2022.
Nuti F, Krausz C. X-Linked Genes and Spermatogenic Failure. Hum Reprod Update. 2021.
Li LX, Zhang HD, Wang Q. Novel Mutations in X-Linked Spermatogenic Failure Genes: A Prospective Cohort Study. J Urol. 2020.
Chen Y, Anderson AN, Tüttelmann F. Genetic Etiology of Non-Obstructive Azoospermia: A Systematic Review and Meta-Analysis. Fertil Steril. 2023.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure X Linked 8 C5935568. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy