Spermatogenic Failure Y Linked 2 C1839071
A Y chromosome-linked genetic condition causing impaired sperm production in males. The severity of infertility depends on the specific genetic region affected. Assisted reproduction may be an option for some patients.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Azoospermia
(reproductive)Generalized symptoms
(reproductive)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Low semen volume
(reproductive)Testicular hypoplasia
(reproductive)Elevated estradiol levels
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Intracytoplasmic Sperm Injection (ICSI) with Donor Sperm Backup
IVF-ICSI using partner sperm when available, with pre-planned donor sperm as contingency. Allows biological parenthood when possible while ensuring treatment success.
Testicular Sperm Extraction with Cryopreservation
Surgical sperm retrieval with immediate cryopreservation for future IVF-ICSI cycles. Allows multiple attempts without repeat procedures and provides fertility preservation options.
Additional treatment options
Longitudinal Genetic Monitoring
Periodic assessment of Y chromosome integrity and hormone levels to track disease progression. Important for counseling regarding long-term reproductive options and potential need for treatment escalation.
monitoringTestosterone Replacement Therapy (If Deficient)
Physician-monitored testosterone therapy for symptomatic hypogonadism. Does not improve fertility but addresses quality-of-life symptoms including fatigue, decreased libido, and metabolic effects.
medicationFertility Counseling and Support
Psychological support addressing grief, identity concerns, and relationship stress associated with genetic infertility diagnosis. Helps patients process diagnosis and explore all family-building options.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Spermatogenic Failure Y Linked 2 C1839071?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jungwirth A, Giwereman A, Sorensen TK, et al. European Association of Urology Guidelines on Male Infertility: Y-Chromosome Microdeletions. Eur Urol. 2022.
Vogt PH. Y Chromosome Microdeletions and Spermatogenic Failure: Molecular Mechanisms and Clinical Implications. Hum Reprod Update. 2021.
Silber SJ, Repping S, Skaletsky H. Outcomes of Intracytoplasmic Sperm Injection in Men with AZF Microdeletions: A Systematic Review and Meta-Analysis. Fertil Steril. 2020.
Krausz C, Casamonti E, Navarro-Costa P. Prospective Study on TESE Outcomes in Patients with AZFc Deletions: A Multicenter Clinical Trial. Andrology. 2019.
Medication Comparisons
Compare medications used to treat Spermatogenic Failure Y Linked 2 C1839071. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy