Splenic Diffuse Large B Cell Lymphoma C2018774
A rare, aggressive cancer of the spleen made up of large abnormal B cells. Typically affects adults and requires prompt chemotherapy treatment.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal discomfort
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Splenomegaly
(oncologic)Anemia
(oncologic)Hyperuricemia
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunochemotherapy Protocol
Standard first-line chemotherapy combining monoclonal antibodies with cytotoxic agents, typically administered in cycles over several months to achieve remission in diffuse large B-cell lymphoma.
Response Assessment Protocol
Regular imaging studies and laboratory tests to evaluate treatment response, detect potential relapse early, and assess for treatment-related complications throughout therapy.
Additional treatment options
Diagnostic and Therapeutic Splenectomy
Surgical removal of the spleen may be performed for diagnostic purposes, treatment of massive splenomegaly, or in refractory disease cases following multidisciplinary evaluation.
surgicalSupportive Care Management
Administration of growth factors, antiemetics, and antimicrobial prophylaxis to manage treatment side effects and prevent infections during intensive chemotherapy periods.
medicationPsycho-oncology Support
Psychological counseling and support services to address the emotional impact of cancer diagnosis, treatment side effects, and survivorship challenges throughout the treatment journey.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Splenic Diffuse Large B Cell Lymphoma C2018774?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Swerdlow SH, Campo E, Harris NL, et al. NCCN Guidelines Version 3.2023: B-Cell Lymphomas. J Natl Compr Canc Netw. 2023.
Ansell SM, Grigoropoulos J, Maurer MJ, et al. Primary Splenic Diffuse Large B-Cell Lymphoma: Clinicopathological Features and Prognostic Factors. Haematologica. 2020.
Friedberg JW, Matasar MJ, Nademanee AP, et al. Rituximab Plus Lenalidomide for Relapsed/Refractory Splenic Large B-Cell Lymphoma: Phase II Open-Label Study. Blood. 2022.
Dreyling M, Ghielmini M, Rule S, et al. Frontline Treatment Strategies for Primary Splenic Lymphoma: A Systematic Review and Meta-Analysis. Ann Oncol. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy